Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice.
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice.
Auteurs : P. Arda-Pirincci [Turquie] ; O. Sacan [Turquie] ; C. Ozal-Coskun [Turquie] ; G. Aykol-Celik [Turquie] ; O. Karabulut-Bulan [Turquie] ; R. Yanardag [Turquie] ; S. Bolkent [Turquie]Source :
- Human & experimental toxicology [ 1477-0903 ] ; 2020.
Descripteurs français
- KwdFr :
- Agents protecteurs (pharmacologie), Animaux (MeSH), Apoptose (effets des médicaments et des substances chimiques), Apoptose (immunologie), Caspase-3 (génétique), Cyclooxygenase 2 (génétique), Cytokines (métabolisme), Foie (anatomopathologie), Foie (effets des médicaments et des substances chimiques), Foie (enzymologie), Galectine 1 (pharmacologie), Injections péritoneales (MeSH), Lésions hépatiques dues aux substances (anatomopathologie), Lésions hépatiques dues aux substances (enzymologie), Lésions hépatiques dues aux substances (immunologie), Lésions hépatiques dues aux substances (prévention et contrôle), Modèles animaux de maladie humaine (MeSH), Prolifération cellulaire (effets des médicaments et des substances chimiques), Protéines recombinantes (pharmacologie), Rectocolite hémorragique (complications), Souris de lignée C57BL (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Stress oxydatif (génétique), Stress oxydatif (immunologie), Sulfate dextran (toxicité).
- MESH :
- anatomopathologie : Foie, Lésions hépatiques dues aux substances.
- effets des médicaments et des substances chimiques : Apoptose, Foie, Prolifération cellulaire, Stress oxydatif.
- enzymologie : Foie, Lésions hépatiques dues aux substances.
- génétique : Caspase-3, Cyclooxygenase 2, Rectocolite hémorragique, Stress oxydatif.
- immunologie : Apoptose, Lésions hépatiques dues aux substances, Stress oxydatif.
- métabolisme : Cytokines.
- pharmacologie : Agents protecteurs, Galectine 1, Protéines recombinantes.
- prévention et contrôle : Lésions hépatiques dues aux substances.
- toxicité : Sulfate dextran.
- Animaux, Injections péritoneales, Modèles animaux de maladie humaine, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals (MeSH), Apoptosis (drug effects), Apoptosis (immunology), Caspase 3 (genetics), Cell Proliferation (drug effects), Chemical and Drug Induced Liver Injury (enzymology), Chemical and Drug Induced Liver Injury (immunology), Chemical and Drug Induced Liver Injury (pathology), Chemical and Drug Induced Liver Injury (prevention & control), Colitis, Ulcerative (complications), Cyclooxygenase 2 (genetics), Cytokines (metabolism), Dextran Sulfate (toxicity), Disease Models, Animal (MeSH), Galectin 1 (pharmacology), Injections, Intraperitoneal (MeSH), Liver (drug effects), Liver (enzymology), Liver (pathology), Mice, Inbred C57BL (MeSH), Oxidative Stress (drug effects), Oxidative Stress (genetics), Oxidative Stress (immunology), Protective Agents (pharmacology), Recombinant Proteins (pharmacology).
- MESH :
- chemical , genetics : Caspase 3, Cyclooxygenase 2.
- complications : Colitis, Ulcerative.
- drug effects : Apoptosis, Cell Proliferation, Liver, Oxidative Stress.
- enzymology : Chemical and Drug Induced Liver Injury, Liver.
- genetics : Oxidative Stress.
- immunology : Apoptosis, Chemical and Drug Induced Liver Injury, Oxidative Stress.
- chemical , metabolism : Cytokines.
- pathology : Chemical and Drug Induced Liver Injury, Liver.
- chemical , pharmacology : Galectin 1, Protective Agents, Recombinant Proteins.
- prevention & control : Chemical and Drug Induced Liver Injury.
- chemical , toxicity : Dextran Sulfate.
- Animals, Disease Models, Animal, Injections, Intraperitoneal, Mice, Inbred C57BL.
Abstract
Galectin-1 is an important mediator that regulates the T-cell-mediated immune response. It has many other biological functions such as cell growth, immunomodulation, and wound healing. The aim of this study was to reveal the role of galectin-1 on liver morphology, cell proliferation, apoptosis, inflammatory and anti-inflammatory mediators, oxidative stress, and antioxidant system in colitis-mediated hepatotoxicity induced by dextran sulfate sodium (DSS). In the present study, adult mice were divided into four groups: The control group intraperitoneally injected with phosphate buffer saline (I), the group which was orally administered with DSS (II), the control group which was injected with galectin-1 (III), and the group which was given DSS and galectin-1 (IV). DSS administration caused degenerative changes and diffuse necrotic damage, an increase in caspase-3 and cyclooxygenase-2 expression, the levels of lipid peroxidation and tumor necrosis factor-alpha, lactate dehydrogenase, and myeloperoxidase activities, and a decrease in cell proliferation, interleukin-10 levels, and antioxidant system parameters in liver tissues. Treatment of DSS group with galectin-1 reversed these effects and prevented liver damage. This study showed that galectin-1 has proliferative, antiapoptotic, anti-inflammatory, and antioxidant effects against DSS-induced liver injury in mice. It is expected considering all results of this study that galectin-1 may be useful as a protective agent against liver toxicity.
DOI: 10.1177/0960327119891224
PubMed: 31789064
Affiliations:
Links toward previous steps (curation, corpus...)
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Sacan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Ozal Coskun, C" sort="Ozal Coskun, C" uniqKey="Ozal Coskun C" first="C" last="Ozal-Coskun">C. 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Arda-Pirincci</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Sacan, O" sort="Sacan, O" uniqKey="Sacan O" first="O" last="Sacan">O. Sacan</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Ozal Coskun, C" sort="Ozal Coskun, C" uniqKey="Ozal Coskun C" first="C" last="Ozal-Coskun">C. Ozal-Coskun</name><affiliation wicri:level="1"><nlm:affiliation>Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Aykol Celik, G" sort="Aykol Celik, G" uniqKey="Aykol Celik G" first="G" last="Aykol-Celik">G. Aykol-Celik</name><affiliation wicri:level="1"><nlm:affiliation>Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Karabulut Bulan, O" sort="Karabulut Bulan, O" uniqKey="Karabulut Bulan O" first="O" last="Karabulut-Bulan">O. Karabulut-Bulan</name><affiliation wicri:level="1"><nlm:affiliation>Division of General Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of General Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Yanardag, R" sort="Yanardag, R" uniqKey="Yanardag R" first="R" last="Yanardag">R. Yanardag</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Bolkent, S" sort="Bolkent, S" uniqKey="Bolkent S" first="S" last="Bolkent">S. Bolkent</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human & experimental toxicology</title><idno type="eISSN">1477-0903</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Apoptosis (drug effects)</term><term>Apoptosis (immunology)</term><term>Caspase 3 (genetics)</term><term>Cell Proliferation (drug effects)</term><term>Chemical and Drug Induced Liver Injury (enzymology)</term><term>Chemical and Drug Induced Liver Injury (immunology)</term><term>Chemical and Drug Induced Liver Injury (pathology)</term><term>Chemical and Drug Induced Liver Injury (prevention & control)</term><term>Colitis, Ulcerative (complications)</term><term>Cyclooxygenase 2 (genetics)</term><term>Cytokines (metabolism)</term><term>Dextran Sulfate (toxicity)</term><term>Disease Models, Animal (MeSH)</term><term>Galectin 1 (pharmacology)</term><term>Injections, Intraperitoneal (MeSH)</term><term>Liver (drug effects)</term><term>Liver (enzymology)</term><term>Liver (pathology)</term><term>Mice, Inbred C57BL (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Oxidative Stress (genetics)</term><term>Oxidative Stress (immunology)</term><term>Protective Agents (pharmacology)</term><term>Recombinant Proteins (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agents protecteurs (pharmacologie)</term><term>Animaux (MeSH)</term><term>Apoptose (effets des médicaments et des substances chimiques)</term><term>Apoptose (immunologie)</term><term>Caspase-3 (génétique)</term><term>Cyclooxygenase 2 (génétique)</term><term>Cytokines (métabolisme)</term><term>Foie (anatomopathologie)</term><term>Foie (effets des médicaments et des substances chimiques)</term><term>Foie (enzymologie)</term><term>Galectine 1 (pharmacologie)</term><term>Injections péritoneales (MeSH)</term><term>Lésions hépatiques dues aux substances (anatomopathologie)</term><term>Lésions hépatiques dues aux substances (enzymologie)</term><term>Lésions hépatiques dues aux substances (immunologie)</term><term>Lésions hépatiques dues aux substances (prévention et contrôle)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term><term>Protéines recombinantes (pharmacologie)</term><term>Rectocolite hémorragique (complications)</term><term>Souris de lignée C57BL (MeSH)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Stress oxydatif (génétique)</term><term>Stress oxydatif (immunologie)</term><term>Sulfate dextran (toxicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Caspase 3</term><term>Cyclooxygenase 2</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term><term>Lésions hépatiques dues aux substances</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Colitis, Ulcerative</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Proliferation</term><term>Liver</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term><term>Foie</term><term>Prolifération cellulaire</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Foie</term><term>Lésions hépatiques dues aux substances</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Caspase-3</term><term>Cyclooxygenase 2</term><term>Rectocolite hémorragique</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Apoptose</term><term>Lésions hépatiques dues aux substances</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Apoptosis</term><term>Chemical and Drug Induced Liver Injury</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents protecteurs</term><term>Galectine 1</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Galectin 1</term><term>Protective Agents</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Lésions hépatiques dues aux substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Dextran Sulfate</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Sulfate dextran</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Injections, Intraperitoneal</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Injections péritoneales</term><term>Modèles animaux de maladie humaine</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Galectin-1 is an important mediator that regulates the T-cell-mediated immune response. It has many other biological functions such as cell growth, immunomodulation, and wound healing. The aim of this study was to reveal the role of galectin-1 on liver morphology, cell proliferation, apoptosis, inflammatory and anti-inflammatory mediators, oxidative stress, and antioxidant system in colitis-mediated hepatotoxicity induced by dextran sulfate sodium (DSS). In the present study, adult mice were divided into four groups: The control group intraperitoneally injected with phosphate buffer saline (I), the group which was orally administered with DSS (II), the control group which was injected with galectin-1 (III), and the group which was given DSS and galectin-1 (IV). DSS administration caused degenerative changes and diffuse necrotic damage, an increase in caspase-3 and cyclooxygenase-2 expression, the levels of lipid peroxidation and tumor necrosis factor-alpha, lactate dehydrogenase, and myeloperoxidase activities, and a decrease in cell proliferation, interleukin-10 levels, and antioxidant system parameters in liver tissues. Treatment of DSS group with galectin-1 reversed these effects and prevented liver damage. This study showed that galectin-1 has proliferative, antiapoptotic, anti-inflammatory, and antioxidant effects against DSS-induced liver injury in mice. It is expected considering all results of this study that galectin-1 may be useful as a protective agent against liver toxicity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31789064</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1477-0903</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Human & experimental toxicology</Title><ISOAbbreviation>Hum Exp Toxicol</ISOAbbreviation></Journal><ArticleTitle>Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice.</ArticleTitle><Pagination><MedlinePgn>423-432</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/0960327119891224</ELocationID><Abstract><AbstractText>Galectin-1 is an important mediator that regulates the T-cell-mediated immune response. It has many other biological functions such as cell growth, immunomodulation, and wound healing. The aim of this study was to reveal the role of galectin-1 on liver morphology, cell proliferation, apoptosis, inflammatory and anti-inflammatory mediators, oxidative stress, and antioxidant system in colitis-mediated hepatotoxicity induced by dextran sulfate sodium (DSS). In the present study, adult mice were divided into four groups: The control group intraperitoneally injected with phosphate buffer saline (I), the group which was orally administered with DSS (II), the control group which was injected with galectin-1 (III), and the group which was given DSS and galectin-1 (IV). DSS administration caused degenerative changes and diffuse necrotic damage, an increase in caspase-3 and cyclooxygenase-2 expression, the levels of lipid peroxidation and tumor necrosis factor-alpha, lactate dehydrogenase, and myeloperoxidase activities, and a decrease in cell proliferation, interleukin-10 levels, and antioxidant system parameters in liver tissues. Treatment of DSS group with galectin-1 reversed these effects and prevented liver damage. This study showed that galectin-1 has proliferative, antiapoptotic, anti-inflammatory, and antioxidant effects against DSS-induced liver injury in mice. It is expected considering all results of this study that galectin-1 may be useful as a protective agent against liver toxicity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arda-Pirincci</LastName><ForeName>P</ForeName><Initials>P</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7958-6977</Identifier><AffiliationInfo><Affiliation>Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sacan</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozal-Coskun</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aykol-Celik</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Section of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karabulut-Bulan</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Division of General Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yanardag</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Biochemistry, Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bolkent</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Molecular Biology, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>12</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Hum Exp Toxicol</MedlineTA><NlmUniqueID>9004560</NlmUniqueID><ISSNLinking>0960-3271</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D037483">Galectin 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020011">Protective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9042-14-2</RegistryNumber><NameOfSubstance UI="D016264">Dextran Sulfate</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.-</RegistryNumber><NameOfSubstance UI="C077623">Ptgs2 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.99.1</RegistryNumber><NameOfSubstance UI="D051546">Cyclooxygenase 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D053148">Caspase 3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053148" MajorTopicYN="N">Caspase 3</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056486" MajorTopicYN="N">Chemical and Drug Induced Liver Injury</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003093" MajorTopicYN="N">Colitis, Ulcerative</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051546" MajorTopicYN="N">Cyclooxygenase 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016264" MajorTopicYN="N">Dextran Sulfate</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D037483" MajorTopicYN="N">Galectin 1</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007274" MajorTopicYN="N">Injections, Intraperitoneal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020011" MajorTopicYN="N">Protective Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Dextran sulfate sodium</Keyword><Keyword MajorTopicYN="N">galectin-1</Keyword><Keyword MajorTopicYN="N">hepatotoxicity</Keyword><Keyword MajorTopicYN="N">mouse</Keyword><Keyword MajorTopicYN="N">ulcerative colitis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31789064</ArticleId><ArticleId IdType="doi">10.1177/0960327119891224</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Arda Pirincci, P" sort="Arda Pirincci, P" uniqKey="Arda Pirincci P" first="P" last="Arda-Pirincci">P. Arda-Pirincci</name></noRegion><name sortKey="Aykol Celik, G" sort="Aykol Celik, G" uniqKey="Aykol Celik G" first="G" last="Aykol-Celik">G. Aykol-Celik</name><name sortKey="Bolkent, S" sort="Bolkent, S" uniqKey="Bolkent S" first="S" last="Bolkent">S. Bolkent</name><name sortKey="Karabulut Bulan, O" sort="Karabulut Bulan, O" uniqKey="Karabulut Bulan O" first="O" last="Karabulut-Bulan">O. Karabulut-Bulan</name><name sortKey="Ozal Coskun, C" sort="Ozal Coskun, C" uniqKey="Ozal Coskun C" first="C" last="Ozal-Coskun">C. Ozal-Coskun</name><name sortKey="Sacan, O" sort="Sacan, O" uniqKey="Sacan O" first="O" last="Sacan">O. Sacan</name><name sortKey="Yanardag, R" sort="Yanardag, R" uniqKey="Yanardag R" first="R" last="Yanardag">R. Yanardag</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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